Pharmacokinetics of caspofungin increased dosage in a patient on rifampin-containing anti-tubercular treatment

Autor:	Lorena Baietto, Francesco Giuseppe De Rosa, Roberto Bertucci, Andrea Calcagno, Roberto Rostagno, Antonio D'Avolio, Nicole Pagani, Giovanni Di Perri
Rok vydání:	2013
Předmět:	Male Microbiology (medical) Antifungal Agents Tuberculosis Antitubercular Agents Pharmacology Echinocandins Lipopeptides Plasma chemistry.chemical_compound Pharmacokinetics Caspofungin Clinical investigation polycyclic compounds Humans Medicine Drug Interactions Enzyme inducer Anti tubercular General Immunology and Microbiology biology business.industry General Medicine Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Infectious Diseases Plasma exposure chemistry Plasma chemistry biology.protein Rifampin business
Zdroj:	Scandinavian Journal of Infectious Diseases. 45:882-884
ISSN:	1651-1980 0036-5548
Popis:	We describe a patient treated with caspofungin and rifampin; after increasing the dosage of the former (70 mg/day) we observed an unexpectedly lower plasma exposure (AUC0-24 79.5 μg/ml*h vs. 108.8 μg/ml*h). Although rifampin-mediated complete enzyme induction may take longer than 2 weeks, the clinical advantage of an increased caspofungin dose deserves clinical investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51425feb4b02b9806c4fa8641e62a2e https://doi.org/10.3109/00365548.2013.800226 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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