Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease: a diagnostic accuracy systematic review and individual participant data pooled analysis
| Autor: | Frank H. Miller, Sudhakar K. Venkatesh, Richard L. Ehman, Zhen Wang, Russell N. Low, Jayant A. Talwalkar, Rohit Loomba, Tarek Hassanein, David J. Lomas, Meng Yin, Mohammad Hassan Murad, Patrick Asbach, Jun Chen, Claude B. Sirlin, Siddharth Singh, Edmund M. Godfrey |
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| Rok vydání: | 2016 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Biopsy Chronic Liver Disease and Cirrhosis Clinical Sciences Gastroenterology Sensitivity and Specificity Article Oral and gastrointestinal 030218 nuclear medicine & medical imaging Hepatitis 03 medical and health sciences 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Clinical Research Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Obesity Stage (cooking) medicine.diagnostic_test business.industry Liver Disease Fatty liver General Medicine Gold standard (test) Biomarker Middle Aged medicine.disease Magnetic resonance elastography Nuclear Medicine & Medical Imaging Good Health and Well Being Liver Liver biopsy Elasticity Imaging Techniques 030211 gastroenterology & hepatology Female Radiology Diagnostic performance business Elastography Digestive Diseases |
| Zdroj: | European radiology, vol 26, iss 5 Singh, S; Venkatesh, SK; Loomba, R; Wang, Z; Sirlin, C; Chen, J; et al.(2016). Magnetic resonance elastography for staging liver fibrosis in non-alcoholic fatty liver disease: a diagnostic accuracy systematic review and individual participant data pooled analysis. European Radiology, 26(5), 1431-1440. doi: 10.1007/s00330-015-3949-z. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7nk1k5t7 |
| Popis: | © 2015, European Society of Radiology. Objectives: We conducted an individual participant data (IPD) pooled analysis on diagnostic accuracy of MRE to detect fibrosis stage in patients with non-alcoholic fatty liver disease (NAFLD). Methods: Through a systematic literature search, we identified studies of MRE (at 60–62.5 Hz) for staging fibrosis in patients with NAFLD, using liver biopsy as gold standard, and contacted study authors for IPD. Through pooled analysis, we calculated the cluster-adjusted AUROC, sensitivity and specificity of MRE for any (≥stage 1), significant (≥stage 2) and advanced (≥stage 3) fibrosis and cirrhosis (stage 4). Results: We included nine studies with 232 patients with NAFLD (mean age, 51 ± 13 years; 37.5 % males; mean BMI, 33.5 ± 6.7 kg/m2; interval between MRE and biopsy |
| Databáze: | OpenAIRE |
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