Neuropsychological impairments associated with severity of Parkinson's disease
Autor: | S J, Huber, D L, Freidenberg, E C, Shuttleworth, G W, Paulson, J A, Christy |
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Rok vydání: | 1989 |
Předmět: |
Male
medicine.medical_specialty Disease Neuropsychological Tests medicine Humans Psychiatry Depression (differential diagnoses) Aged Depressive Disorder medicine.diagnostic_test Verbal Behavior Neuropsychology Parkinson Disease Cognition Neuropsychological test Middle Aged medicine.disease Somatic psychology Psychiatry and Mental health Mood Schizophrenia Mental Recall Speech Perception Dementia Female Neurology (clinical) Cognition Disorders Mental Status Schedule Psychology Psychomotor Performance Clinical psychology |
Zdroj: | The Journal of Neuropsychiatry and Clinical Neurosciences. 1:154-158 |
ISSN: | 1545-7222 0895-0172 |
DOI: | 10.1176/jnp.1.2.154 |
Popis: | Intellectual impairment and disease severity tend to parallel one another in patients with Parkinson’s disease (PD), but the pattern of development of the neuro psychological impairments contributing to the overall intellectual decline is unknown. This problem was addressed by comparing neuropsychological performance in the early and later stages of PD. Impairment of recent memory, impairment of cognition, and somatic features of depression were seen early and worsened with more advanced disease. Impairment of visuospatial skills, remote memory, language, and mood were observed only in the later stages of PD. These findings suggest that neuropsychological impairments do not develop in a uniform manner with progression of PD. I n his original essay on “the shaking palsy,” James Parkinson’ suggested this disease leaves the senses and intellect intact. Many researchers disagree and feel that most, perhaps all, Parkinson’s disease (PD) patients eventually develop cognitive disturbances. Many also agree that the overall severity of intellectual disturbance and severity of the clinical disease are positively correlated,2� although which specific quantitative and/or qualitative neuropsychological factors produce the overall intellectual decline at different stages of PD remain unclear. We compared early PD patients to patients in advanced stages and to normal controls with a neuropsychological test battery that measures several areas of cognitive function. Our purpose was to identify neuropsychological features that are impaired early and determine whether they worsened in more advanced PD (quantitative differences), and to identify processes that are normal in the early stages and become impaired only in advanced stages of PD (qualitative changes). |
Databáze: | OpenAIRE |
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