Vagus nerve stimulation: longitudinal follow-up of patients treated for 5 years
| Autor: | Tomas Prochazka, Věra Sebroňová, Klára Brožová, Hana Ošlejšková, Petr Marusic, Robert Kuba, Jan Hadač, Ivan Rektor, Miroslav Kalina, Jana Zárubová, Milan Brázdil, Jiří Hovorka, Tomáš Nežádal, Vladimir Komarek |
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| Rok vydání: | 2008 |
| Předmět: |
Time Factors
Adolescent Vagus Nerve Stimulation medicine.medical_treatment Concordance Clinical Neurology Stimulation 03 medical and health sciences Epilepsy 0302 clinical medicine Medicine Humans 030212 general & internal medicine Longitudinal Studies Adverse effect Child Czech Republic Pain Measurement Retrospective Studies Seizure frequency business.industry Retrospective cohort study General Medicine medicine.disease 3. Good health Clinical Practice Treatment Outcome Neurology Anesthesia Child Preschool Neurology (clinical) business 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Seizure. 18(4) |
| ISSN: | 1059-1311 |
| Popis: | We performed a retrospective, multicenter, open-label study to evaluate the efficacy of vagus nerve stimulation (VNS) in all patients in the Czech Republic who have received this treatment for at least 5 years (n=90). The mean last follow-up was 6.6+/-1.1 years (79+/-13 months). The median number of seizures among all patients decreased from 41.2 seizures/month in the prestimulation period to 14.9 seizures/month at 5 years follow-up visit. The mean percentage of seizure reduction was 55.9%. The responder rate in these patients is in concordance with the decrease of overall seizure frequency. At 1 year after beginning the stimulation, 44.4% of patients were responders; this percentage increased to 58.7% after 2 years. At the 5 years last follow-up 64.4% of patients were responders, 15.5% experienced > or = 90% seizure reduction, and 5.5% were seizure-free. A separate analysis of patients younger than 16 years of age showed lower efficacy rates of VNS in comparison to the whole group. Complications and chronic adverse effects occurred in 13.3% of patients. VNS is an effective and safe method to refractory epilepsy in common clinical practice. |
| Databáze: | OpenAIRE |
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