Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer

Autor: Puig Rosell, Pere, Erill, Nadina, Terricabras, Marta, Subirana, Isaac, González-García, Judit, Asensi-Puig, Adrià, Donovan, Michael J., Mengual, Lourdes, Agulló-Ortuño, M. Teresa, Olivan, M., Alcaraz, Antonio, López-Martín, José A., de Torres, Inés, Rodríguez-Peralto, José Luis, Rodríguez-Antolín, Alfredo, Morote Robles, Juan, González-Rumayor, Víctor, Universitat Autònoma de Barcelona
Přispěvatelé: Institut Català de la Salut, [Puig P, Erill N, Terricabras M, Subirana I, González-García J, Asensi-Puig A] R&D Department, Atrys Health, Barcelona, Spain. [Olivan M, De Torres I, Morote J] Grup de Recerca Biomèdica en Urologia, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus, Hospital Universitari Vall d'Hebron
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Active β-catenin
Cell
Fluorescent Antibody Technique
lcsh:Medicine
Other subheadings::/analysis [Other subheadings]
Amino Acids
Peptides
and Proteins::Proteins::Armadillo Domain Proteins::beta Catenin [CHEMICALS AND DRUGS]
Otros calificadores::Otros calificadores::Otros calificadores::/enzimología [Otros calificadores]
Prostate cancer
0302 clinical medicine
aminoácidos
péptidos y proteínas::proteínas::proteínas del dominio armadillo::beta catenina [COMPUESTOS QUÍMICOS Y DROGAS]
Prostate
030212 general & internal medicine
lcsh:QH301-705.5
beta Catenin
fenómenos químicos::fenómenos bioquímicos::transducción de señales [FENÓMENOS Y PROCESOS]
Enzimologia
medicine.diagnostic_test
Otros calificadores::/análisis [Otros calificadores]
Biochemical markers
Wnt signaling pathway
General Medicine
Middle Aged
Up-Regulation
Research Note
medicine.anatomical_structure
HLA class1
Marcadors bioquímics
Chemical Phenomena::Biochemical Phenomena::Signal Transduction [PHENOMENA AND PROCESSES]
Biomarker (medicine)
Adult
Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms
Male::Prostatic Neoplasms [DISEASES]
Immunofluorescence
General Biochemistry
Genetics and Molecular Biology
Immunofluorescència
03 medical and health sciences
Downregulation and upregulation
medicine
Biomarkers
Tumor
Humans
Wnt/β-catenin pathway
lcsh:Science (General)
Aged
Càncer de pròstata
Pròstata - Càncer
business.industry
lcsh:R
Prostatic Neoplasms
Proteins
medicine.disease
neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata [ENFERMEDADES]
030104 developmental biology
lcsh:Biology (General)
Catenin
Cancer research
Systems pathology
business
Proteïnes
Other subheadings::Other subheadings::Other subheadings::/enzymology [Other subheadings]
lcsh:Q1-390
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
BMC Research Notes, Vol 12, Iss 1, Pp 1-5 (2019)
BMC Research Notes
Dipòsit Digital de la UB
Universidad de Barcelona
Popis: Prostate cancer; Systems pathology; Wnt/β-catenin pathway Càncer de pròstata; Patologia de sistemes; Via Wnt/β-catenina Cáncer de próstata; Patología de sistemas; Vía Wnt/β-catenina OBJECTIVES: To apply a systems pathology-based approach to the quantification of nuclear Active β-catenin and human leukocyte antigen class I, and assess the biomarker involvement in a cohort of prostate tumor patients. RESULTS: The systems pathology approach applied allows a precise quantification of the marker expression in the different cell compartments as well as the determination of the areas that coexpress two markers. Our data shows that the accumulation of β-catenin in the nuclear compartment is significantly decreased in the adjacent normal areas when compared to tumor of the same patients (p
Databáze: OpenAIRE
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