Association between Helicobacter pylori infection and mild cognitive impairment
| Autor: | Marina Boziki, Nikolaos Kapetanakis, Emmanuel Gavalas, Ioannis Venizelos, Christos Stergiopoulos, Dimitrios Chatzopoulos, Christos Zavos, Magda Tsolaki, Jannis Kountouras |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Atrophic gastritis Chronic gastritis Gastroenterology Helicobacter Infections Serology Internal medicine mental disorders Biopsy Confidence Intervals Humans Medicine Prospective Studies Prospective cohort study Homocysteine Aged Aged 80 and over Chi-Square Distribution Helicobacter pylori medicine.diagnostic_test biology business.industry Odds ratio Middle Aged medicine.disease biology.organism_classification Neurology Gastritis Immunoglobulin G Immunology Female Neurology (clinical) medicine.symptom Cognition Disorders business |
| Zdroj: | European Journal of Neurology. 14:976-982 |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | The association of Helicobacter pylori infection and Alzheimer's disease (AD) has recently been addressed, but no relative data exist regarding mild cognitive impairment (MCI), a prodromal phase of AD. The aim of this prospective study was to evaluate H. pylori infection, by histology in a Greek MCI cohort. Sixty-three consecutive patients with amnestic MCI and 35 normal controls underwent upper gastrointestinal endoscopy, histologic and serological examinations. The prevalence of H. pylori infection was 88.9% (56/63) in MCI patients and 48.6% (17/35) in anaemic controls, as confirmed by biopsy (P < 0.001, odds ratio: 8.47, 95% CI: 3.03-23.67). Mean serum anti-H. pylori IgG concentration and plasma total homocysteine (Hcy) titre were higher in MCI patients than controls (74.86 +/- 57.22 vs. 17.37 +/- 9.30 U/ml; and 16.03 +/- 4.28 vs. 13.5 +/- 1.20 micromol/l; P < 0.001 and P = 0.015, respectively). When compared with the anaemic participants, MCI patients exhibited more often multifocal (body and antral) gastritis (92.1% vs. 68.6%; P = 0.03); in H. pylori positive MCI patients cognitive state correlated with serum anti-H. pylori IgG concentration. In conclusion, H. pylori prevalence was significantly higher in MCI patients than controls. This infection might contribute, at least in part, to the pathophysiology of MCI, possibly through induction of chronic atrophic gastritis and elevated Hcy consequences. |
| Databáze: | OpenAIRE |
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