Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey
| Autor: | Xi Chen, Lu Hao, Qing Zhou, Qiuyan Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Article Subject National Health and Nutrition Examination Survey Bilirubin Biochemistry Gastroenterology chemistry.chemical_compound Serum total bilirubin Internal medicine Humans Medicine Prospective cohort study Telomere Shortening Aged QH573-671 Multivariable linear regression business.industry Cell Biology General Medicine Increased bilirubin Middle Aged Telomere Nutrition Surveys United States chemistry Quartile Linear Models Regression Analysis Female Cytology business Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Introduction. Mildly increased bilirubin concentration has a protective effect on oxidative stress–related diseases. However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association between total bilirubin concentration and telomere length. Methods. We used the data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. The multivariable linear regression model was used to examine the association between total bilirubin concentration and telomere length. The nonlinear relationship was analyzed using a generalized additive model with the smoothing plot. Results. A total of 7818 participants with a mean age of 49.20 ± 18.82 years were included. Compared with the lowest concentration of total bilirubin (Q1), the highest quartile of total bilirubin concentration was associated with longer telomere length in male ( β = 0.04 , 95 CI%: 0.00, 0.07, P = 0.024 ) and female ( β = 0.04 , 95 CI%: 0.02, 0.04, P = 0.002 ). Furthermore, an inverted U-shaped relationship between total bilirubin and telomere length was found. On the left of turning points ( total bilirubin < 0.5 mg / dL ), total bilirubin concentration was positively associated with telomere length ( β = 0.23 , 95 CI%: 0.14, 0.32, P < 0.001 ). However, the association between total bilirubin concentration and telomere length was not significant ( β = 0.01 , 95% CI: -0.01, 0.04, P = 0.346 ) above the turning point. Conclusion. This is the first evidence based on a nationally representative survey demonstrating a positive and nonlinear association between total bilirubin concentration and telomere length. Future large-scale prospective studies are warranted to confirm our findings. |
| Databáze: | OpenAIRE |
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