Enrichment of alpha-linolenic acid in rodent diet reduced oxidative stress and inflammation during myocardial infarction

Autor: Jean-Marie Galano, Thierry Durand, Camille Oger, Jetty Chung-Yung Lee, Kin Sum Leung
Přispěvatelé: The University of Hong Kong (HKU), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2021
Předmět:
0301 basic medicine
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Myocardial Infarction
Rodentia
Isoprostanes
medicine.disease_cause
Biochemistry
Rats
Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Lipid oxidation
Physiology (medical)
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Inflammation
2. Zero hunger
chemistry.chemical_classification
alpha-Linolenic acid
alpha-Linolenic Acid
α-Linolenic acid
Eicosapentaenoic acid
Diet
Rats
3. Good health
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
Docosahexaenoic acid
Phytoprostanes
Polyunsaturated fatty acids
Arachidonic acid
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
030217 neurology & neurosurgery
Oxidative stress
Polyunsaturated fatty acid
Zdroj: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2021, 162, pp.53-64. ⟨10.1016/j.freeradbiomed.2020.11.025⟩
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2020.11.025
Popis: International audience; Myocardial infarction (MI) is an irreversible event caused by cardiac ischemia and may be fatal. Studies reported that increased intake of n-3 polyunsaturated fatty acids (PUFA) namely, eicosapentaenoic acid and docosahexaenoic acid reduce the risk of cardiovascular disease and lower the incidence of MI. Nonetheless, the cardioprotective effect of plant n-3-PUFA such as α-linolenic acid (ALA) in the diet is not conclusive. In this study, Sprague Dawley rats were supplemented with isocaloric diets enriched with ALA rich flaxseed (FS) and flaxseed oil (FSO), and normal chow (Control) for 4 weeks. MI was induced by isoproterenol (ISO) injection. Results showed that all ALA-enriched diets displayed cardioprotection against MI. The heart to body weight ratio, plasma LDH activity and plasma cTnI were reduced compared to ISO and was prominent in FS diet. ALA and EPA were up-regulated in both tissues and plasma by ALA-diets compared to Control and remained higher than ISO groups. Notably, LOX-mediated HETEs decreased whereas LOX-mediated HDHAs were elevated in both tissues and plasma of ALA-enriched diets compared to ISO. In addition, non-enzymatic oxidized products from arachidonic acid including 15-F2t-IsoP were reduced in both tissues and plasma of MI rats supplemented with ALA-enriched diets while those from n-3 PUFAs including F4-NeuroPs, PhytoPs and PhytoFs were elevated compared to control. ALA-enriched diets particularly flaxseed reduced gene expressions of inflammatory cytokines namely IL-1β, IL-6 and TNFα and prevented the down regulation of antioxidant catalase in the heart tissues. In conclusion ALA-enriched diets potentially exerted cardioprotection through the regulation of anti-inflammatory and anti-oxidative mediators from n-3 PUFA autooxidation.
Databáze: OpenAIRE
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