Successful resection of a granulocyte colony-stimulating factor-producing carcinoma of the pancreas: A case report

Autor: Hironori Tsujimoto, Makoto Nishikawa, Hideki Ueno, Takayuki Akasaki, Kenji Yamazaki, Kazuo Hase, Shuichi Hiraki, Hiromi Nagata, Junji Yamamoto, Suefumi Aosasa, Takahiro Einama, Takuji Noro, Eiji Shinto, Mayumi Hoshikawa, Yoshihisa Yaguchi, Keita Tashiro, Akifumi Kimura, Yoshiki Kajiwara, Sho Ogata
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular and Clinical Oncology
ISSN: 2049-9469
2049-9450
Popis: Granulocyte colony-stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation of precursor cells in the bone marrow and their maturation into fully differentiated neutrophils. G-CSF-producing cancers rarely occur in the digestive system, particularly the pancreas. Herein we report the rare case of a G-CSF-producing pancreatic carcinoma associated with severe anemia due to bleeding in the duodenum, which was successfully treated with surgery. A 79 year-old man presented with epigastralgia and anemia at our institution. Esophagogastroduodenoscopy revealed a duodenal tumor, which was diagnosed as a poorly differentiated adenocarcinoma. To control breeding, subtotal stomach-preserving pancreaticoduodenectomy was performed. The excised tumor measured 86×55×54 mm. It was primarily located in the pancreas and compressed the pancreatic parenchyma and main bile duct. It comprised poorly differentiated adenocarcinoma, and prominent neutrophil infiltration was noted around the tumor. Immunohistochemical examination revelaed that the tumor was positive for G-CSF expression. Based on these results, a final diagnosis of G-CSF-producing primary pancreatic cancer was made. At 18 months following surgery, the patient was alive without recurrence.
Databáze: OpenAIRE
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