The loss of tolerance to CHI3L1 – A putative role in inflammatory bowel disease?
| Autor: | Peter Schierack, Claudia Deutschmann, Dirk Roggenbuck |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Neutrophils Immunology Autoimmunity Context (language use) Disease medicine.disease_cause digestive system Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Immune system Immune Tolerance medicine Genetic predisposition Humans Immunology and Allergy Chitinase-3-Like Protein 1 Intestinal Mucosa business.industry Macrophages Inflammatory Bowel Diseases medicine.disease Acquired immune system Ulcerative colitis digestive system diseases Gastrointestinal Microbiome Toll-Like Receptor 4 030104 developmental biology business 030215 immunology |
| Zdroj: | Clinical Immunology. 199:12-17 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2018.12.005 |
| Popis: | The incidence of inflammatory bowel disease (IBD) is steadily increasing. IBD is characterized by chronic inflammation of the gastrointestinal tract and is divided into the two main entities Crohn's disease (CD) and ulcerative colitis (UC). Genetic predispositions, environmental factors and a dysregulated immune response are known to be involved at the beginning of IBD. However, their etiopathogenesis is not yet fully understood. Over the last ten years, there has been increasing evidence of the involvement of the member of the 18-glycosylhydrolase family chitinase-3-like protein 1 (CHI3L1) in IBD. CHI3L1 is associated with various diseases such as cancer and chronic inflammatory diseases including rheumatoid arthritis or IBD as well as neurological diseases where it can act as a chemoattractant, mitogen or growth factor. This review will focus on the role of autoimmunity to CHI3L1 in IBD in the context of its expression in inflamed colonic epithelia and interaction with intestinal microbiota. Further, it will provide insights into the interaction of CHI3L1 with different mechanisms of the innate and adaptive immune response in IBD. |
| Databáze: | OpenAIRE |
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