Studying the neuropsychological sequelae of SARS-CoV-2: lessons learned from 35 years of neuroHIV research

Autor: James T. Becker, Andrew J. Levine, Ned Sacktor
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.medical_specialty
Neurology
AIDS Dementia Complex
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viruses
Clinical Sciences
Clinical Neurology
Review
Vaccine Related
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
HIV-associated neurocognitive disorders
Clinical Research
Neuropsychology
Virology
Epidemiology
Medicine
Humans
Intensive care medicine
Lung
NeuroHIV
business.industry
SARS-CoV-2
Incidence (epidemiology)
Prevention
Neurosciences
COVID-19
Cognition
Pneumonia
030104 developmental biology
Emerging Infectious Diseases
Infectious Diseases
Medical Microbiology
Pneumonia & Influenza
HIV/AIDS
Mental health
Neurology (clinical)
Nervous System Diseases
business
Infection
Neurocognitive
030217 neurology & neurosurgery
Cohort study
Zdroj: Journal of Neurovirology
Journal of neurovirology, vol 26, iss 6
Journal of NeuroVirology
ISSN: 1538-2443
1355-0284
Popis: The virology of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the human immune response to the virus are under vigorous investigation. There are now several reports describing neurological symptoms in individuals who develop coronavirus disease 2019 (COVID-19), the syndrome associated with SARS-CoV-2 infection. The prevalence, incidence, and clinical course of these symptoms will become clearer in the coming months and years through epidemiological studies. However, the long-term neurological and cognitive consequence of SARS-CoV-2 infection will remain conjectural for some time and will likely require the creation of cohort studies that include uninfected individuals. Considering the early evidence for neurological involvement in COVID-19 it may prove helpful to compare SARS-CoV-2 with another endemic and neurovirulent virus, human immunodeficiency virus-1 (HIV-1), when designing such cohort studies and when making predictions about neuropsychological outcomes. In this paper, similarities and differences between SARS-CoV-2 and HIV-1 are reviewed, including routes of neuroinvasion, putative mechanisms of neurovirulence, and factors involved in possible long-term neuropsychological sequelae. Application of the knowledge gained from over three decades of neuroHIV research is discussed, with a focus on alerting researchers and clinicians to the challenges in determining the cause of neurocognitive deficits among long-term survivors.
Databáze: OpenAIRE
Externí odkaz: