Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications

Autor: Elisabeth Garanger, Jan C. M. van Hest, Evangelos Georgilis, Jan Pille, Sébastien Lecommandoux, Esra Aydinlioglu, Mona Abdelghani
Přispěvatelé: Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Team 3 LCPO : Polymer Self-Assembly & Life Sciences, Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Eindhoven University of Technology [Eindhoven] (TU/e), ANR-14-CE08-0013,LightLab,Développement de polymersomes avec possibilité de suivi par imagerie et activation à distance pour la libération de composés d'intérêt thérapeutique dans des tissus profonds(2014), ANR-15-CE07-0002,ELP,Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis(2015), European Project: 676137,H2020,H2020-MSCA-ITN-2015,NANOMED(2016), Bio-Organic Chemistry, ICMS Core, Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)
Rok vydání: 2020
Předmět:
Drug Carriers/chemistry
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Pharmaceutical Science
Nanoparticle
Nanotechnology
Synthetic proteins
02 engineering and technology
Peptides/chemistry
030226 pharmacology & pharmacy
03 medical and health sciences
0302 clinical medicine
Drug Delivery Systems
In vivo
Self-assembled nanoparticles
Animals
Humans
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Drug Carriers
Chemistry
Polypeptides
Proteins
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
021001 nanoscience & nanotechnology
Biocompatible material
Nanoparticles/administration & dosage
3. Good health
Clinical Practice
Protein materials
Nanomedicine
[CHIM.POLY]Chemical Sciences/Polymers
Drug Design
Drug delivery
Nanoparticles
Nanocarriers
0210 nano-technology
Peptides
[PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]
Nanomedecine
Proteins/chemistry
Zdroj: International Journal of Pharmaceutics
International Journal of Pharmaceutics, 2020, 586, pp.119537. ⟨10.1016/j.ijpharm.2020.119537⟩
International Journal of Pharmaceutics, 586:119537. Elsevier
INTERNATIONAL JOURNAL OF PHARMACEUTICS
International Journal of Pharmaceutics, Elsevier, 2020, 586, pp.119537. ⟨10.1016/j.ijpharm.2020.119537⟩
ISSN: 1873-3476
0378-5173
DOI: 10.1016/j.ijpharm.2020.119537⟩
Popis: International audience; Medicine formulations at the nanoscale, referred to as nanomedicines, have managed to overcome key challenges encountered during the development of new medical treatments and entered clinical practice, but considerable improvement in terms of local efficacy and reduced toxicity still need to be achieved. Currently, the fourth-generation of nanomedicines is being developed, employing biocompatible nanocarriers that are targeted, multifunctional, and stimuli-responsive. Proteins and polypeptides can fit the standards of an efficient nanovector because of their biodegradability, intrinsic bioactivity, chemical reactivity, stimuli-responsiveness, and ability to participate in complex supramolecular assemblies. These biomacromolecules can be obtained from natural resources, produced in heterologous hosts, or chemically synthesized, allowing for different designs to access suitable carriers for a variety of drugs. To enhance targeting or therapeutic functionality, additional chemical modifications can be applied. This review demonstrates the potential of polypeptide and protein materials for the design of drug delivery nanocarriers with a special focus on their preclinical evaluation in vitro and in vivo.
Databáze: OpenAIRE
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