Prospective diagnostic and prognostic study of copeptin in suspected acute aortic syndromes
| Autor: | Corrado Magnino, Enrico Lupia, Giulia Lucia Massimina Cavalot, Francesca Giachino, Fabio Settanni, Matteo Oddi, Fulvio Morello, Maria Tizzani, Stefania Battista, Peiman Nazerian, Giulio Mengozzi, Alice Ianniello |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aortic Diseases lcsh:Medicine 030204 cardiovascular system & hematology Gastroenterology Article Fibrin Fibrinogen Degradation Products 03 medical and health sciences 0302 clinical medicine Copeptin Interquartile range Internal medicine medicine Back pain Humans Myocardial infarction Prospective Studies lcsh:Science Aged Aged 80 and over Multidisciplinary business.industry lcsh:R Glycopeptides Emergency department Middle Aged medicine.disease Prognosis Confidence interval 030104 developmental biology Acute Disease Biomarker (medicine) lcsh:Q Female Differential diagnosis medicine.symptom business Emergency Service Hospital Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Acute aortic syndromes (AAS) are cardiovascular emergencies with unmet diagnostic needs. Copeptin is released upon stress conditions and is approved for rule-out of myocardial infarction (MI). As MI and AAS share presenting symptoms, stress mechanisms and necessity for rapid diagnosis, copeptin appears as an attractive biomarker also for AAS. We thus performed a diagnostic and observational study in Emergency Department (ED) outpatients. Inclusion criteria were chest/abdominal/back pain, syncope and/or perfusion deficit, plus AAS in differential diagnosis. Blood samples were obtained in the ED. 313 patients were analyzed and 105 (33.5%) were diagnosed with AAS. Median copeptin was 38.91 pmol/L (interquartile range, IQR, 16.33–173.4) in AAS and 7.51 pmol/L (IQR 3.58–15.08) in alternative diagnoses (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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