Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities
| Autor: | Sérgio de Albuquerque, Dênis Pires de Lima, Adilson Beatriz, Aline Alves dos Santos Naujorks, Maria Rita Marques, Rosangela da Silva Lopes, Adriano Olímpio da Silva |
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| Rok vydání: | 2015 |
| Předmět: |
Leishmania
Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Electrospray ionization Organic Chemistry Antiprotozoal Agents Nuclear magnetic resonance spectroscopy Mass spectrometry Trypanocidal Agents Biochemistry Combinatorial chemistry Naphthoquinone Cell Line chemistry.chemical_compound chemistry parasitic diseases Animals Humans Physical and Theoretical Chemistry Amastigote Naphthoquinones |
| Zdroj: | Organic & Biomolecular Chemistry. 13:428-437 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c4ob01869a |
| Popis: | Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive against the promastigote stages of L. chagasi and L. braziliensis. |
| Databáze: | OpenAIRE |
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