High intensity aerobic exercise improves bimanual coordination of grasping forces in Parkinson's disease
| Autor: | A. Elizabeth Jansen, Jay L. Alberts, Mandy Miller Koop, Anson B. Rosenfeldt |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Parkinson's disease Article Upper Extremity 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Basal ganglia Medicine Aerobic exercise Humans Load force Exercise Aged Supplementary motor area business.industry High intensity Motor control Parkinson Disease Middle Aged Hand medicine.disease SMA Exercise Therapy 030104 developmental biology medicine.anatomical_structure Neurology Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Psychomotor Performance |
| Zdroj: | Parkinsonism Relat Disord |
| ISSN: | 1873-5126 |
| Popis: | Introduction Parkinson's disease (PD) disrupts the control and coordination of grasping forces, likely due to a disruption in basal ganglia circuitry and diminished activity within the supplementary motor area (SMA). High intensity aerobic exercise has been shown to enhance connectivity between basal ganglia nuclei and cortical areas, including the SMA. The aim of this project was to determine the effects of high intensity lower extremity exercise on motor control patterns underlying a manual dexterity task. Methods PD participants completed eight weeks of high intensity aerobic exercise under forced or voluntary exercise (FE or VE) modalities. Grasping forces for each limb were quantified during a functional bimanual dexterity task. Data were collected while OFF antiparkinsonian medication at baseline, end of treatment (EOT), and eight weeks after exercise cessation (EOT+8). Results Eight weeks of high intensity exercise improved MDS-UPDRS Motor III clinical ratings by more than 4 points (~15%) for the FE and VE groups. Time to complete the task decreased nearly 30% across both groups as well. The control and coordination of grasping forces, simultaneity of force initiation, and rate of grip and load force exhibited significant improvements following exercise. In general, improvements in biomechanical outcomes were sustained following exercise cessation. Conclusion High intensity aerobic exercise, achieved via a forced or voluntary mode, improved PD symptoms and bimanual dexterity. Sustained improvement of upper extremity motor control following exercise cessation indicates high intensity exercise enhances CNS functioning and suggests exercise may be a candidate for altering PD progression. |
| Databáze: | OpenAIRE |
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