Efficacy of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis
| Autor: | Dawid Storman, Paulina Tobola, Aleksandra M. Swierz, Magdalena Gorecka, Anna Skuza, Wojciech Staskiewicz, Malgorzata M Bala, Mateusz J Swierz, Katarzyna W. Jasinska |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
MEDLINE Bariatric Surgery 030209 endocrinology & metabolism law.invention 03 medical and health sciences 0302 clinical medicine Quality of life Randomized controlled trial Weight loss law Weight Loss medicine Humans Adverse effect business.industry Probiotics Weight change Surgery Obesity Morbid Clinical trial Meta-analysis Quality of Life 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 16(12) |
| ISSN: | 1878-7533 |
| Popis: | Bariatric surgery is considered effective for morbid obesity, and probiotic supplementation might provide some benefits. We aimed to revise the evidence regarding probiotic supplementation in patients with morbid obesity undergoing bariatric surgery. MEDLINE, Embase, Web of Science, CENTRAL, and trial registers were searched up to April 1, 2020. We included randomized controlled trials and controlled clinical trials, and outcomes of interest were weight change, quality of life, gastrointestinal symptoms, and adverse events. All stages of the review were done by 2 authors independently and we followed Cochrane Handbook guidance. We screened 2541 references and included 5 studies. Probiotics may have minor to no effect regarding percentage excess weight loss (%EWL) at 6 weeks (mean difference [MD], .28; 95% CI, −9.53 to 10.09; 44 participants, 2 studies), 3 months (MD, 5.47; 95% CI, −3.22 to 14.17; 165 participants, 3 studies), 6 months (MD, .46; 95% CI, −8.14 to 9.07; 115 participants, 2 studies), and 12 months post surgery (MD, .35; 95% CI, −8.66 to 9.37; 123 participants, 2 studies). We observed short-term improvement in gastrointestinal symptoms. There was no important effect on quality of life and no meaningful adverse events. Because probiotic supplementation might provide some benefit with respect to weight loss, might alleviate some gastrointestinal symptoms, and is associated with minor or no adverse events, continuous supplementation might be worth considering in certain individuals. Our findings are based on the body of evidence of very low certainty, and further well-designed randomized controlled trials are required to elucidate the effect and strengthen the certainty in the estimates. |
| Databáze: | OpenAIRE |
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