Increased circulating malondialdehyde-modified LDL in the patients with familial combined hyperlipidemia and its relation with the hepatic lipase activity
| Autor: | Kouichi Taira, Manabu Shibasaki, Hideaki Bujo, Kazuo Takahashi, Yasushi Saito, Kenya Yamazaki, Naohiro Itou |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Hyperlipidemia Familial Combined Biology chemistry.chemical_compound Polymorphism (computer science) Malondialdehyde Internal medicine Hyperlipidemia Genotype medicine Humans Polymorphism Genetic Triglyceride Cholesterol Cholesterol HDL Cholesterol LDL Lipase Middle Aged medicine.disease Lipoproteins LDL Endocrinology Liver chemistry Female lipids (amino acids peptides and proteins) Hepatic lipase Cardiology and Cardiovascular Medicine Oxidation-Reduction Dyslipidemia |
| Zdroj: | Atherosclerosis. 172:181-187 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2003.05.001 |
| Popis: | Familial combined hyperlipidemia (FCHL) is characterized by elevated levels of serum total cholesterol (TC), triglyceride (TG), or both. The increased incidence of coronary artery diseases (CAD) in the patients with FCHL is believed to be caused by circulating atherogenic lipoproteins associated with the complex phenotype. Recent establishment of sensitive detection system for malondialdehyde-modified (MDA)-LDL, which is one of oxidized lipoproteins, showed its increased circulating level in the patients with CAD. In order to know the atherogenic lipoproteins resulted from the dyslipidemia observed in FCHL, we measured the serum MDA-LDL level in the patients. The circulating MDA-LDL level and the ratio of MDA-LDL and LDL-C in FCHL were significantly higher (P |
| Databáze: | OpenAIRE |
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