TOTAL DOSE IRON INFUSION: SAFETY AND EFFICACY IN PREDIALYSIS PATIENTS

Autor:	Dipankar Bhowmik, Gopesh Modi, Deepak Ray, Sanjay Gupta, Sanjay K. Agarwal, Suresh C. Tiwari, Suresh C. Dash, S C Dash
Rok vydání:	2000
Předmět:	Adult Male medicine.medical_specialty Anemia Iron medicine.medical_treatment Pilot Projects Critical Care and Intensive Care Medicine Gastroenterology Thrombophlebitis Renal Dialysis Internal medicine medicine Humans Infusions Intra-Arterial Saline Aged Anemia Iron-Deficiency business.industry General Medicine Iron deficiency Middle Aged medicine.disease Surgery Iron-deficiency anemia Nephrology Kidney Failure Chronic Female Chills medicine.symptom business Complication Kidney disease
Zdroj:	Renal Failure. 22:39-43
ISSN:	1525-6049 0886-022X
DOI:	10.1081/jdi-100100849
Popis:	Iron deficiency anemia is not uncommon in predialysis patients. Oral iron often cannot maintain adequate iron stores. Hence we evaluated the safety and efficacy of total dose infusion (TDI) of iron in these patients. Anemic predialysis patients were screened and those with Hb < 7.0 g/dL and serum ferritin < 200 ng/mL were selected. Patients with active bleeding and acute liver disease were excluded. All patients were on oral iron 100 mg/day. None of the patients were on erythropoeitin. 11 patients (6 males and 5 females), aged 45.9 +/- 15 yrs, were suitable. Hb was 5.9 +/- 1.0 g/dL and serum ferritin was 89.5 + 50 ng/mL. The preparation used was iron dextran. A test dose of 25 mg in 100 mL normal saline was administered over 1 hr to all patients. One patient had fever and chills during the test dose and was not given TDI. 10 patients received TDI. None of these patients had any problem during the infusion. The dose of iron administered was 900 + 316.2 mg. One patient who received 1600 mg had arthralgia-myalgia and another patient had thrombophlebitis following TDI. One month after TDI, Hb was 8.0 + 1.0 g/dL and serum ferritin was 362 ng/mL. We feel that TDI is a safe and effective method of correcting iron deficiency in predialysis patients.
Databáze:	OpenAIRE
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