Effect of Harmane on the Convulsive Threshold in Epilepsy Models in Mice
| Autor: | Feyza Aricioglu, Okan Yillar, Eylem Korcegez, K. Berkman |
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| Rok vydání: | 2003 |
| Předmět: |
Male
animal structures medicine.drug_class Petit mal Convulsants Pharmacology General Biochemistry Genetics and Molecular Biology Mice Epilepsy History and Philosophy of Science Seizures medicine Animals Harmane Electroshock Benzodiazepine Chemistry General Neuroscience Convulsive threshold medicine.disease Effective dose (pharmacology) Disease Models Animal Harmine Maximal electroshock Grand mal Pentylenetetrazole Female |
| Zdroj: | Annals of the New York Academy of Sciences. 1009:190-195 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1304.023 |
| Popis: | The study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice. Initial studies established convulsive current 50 (CC(50)) values or MES and effective dose 50 (ED(50)) for PTZ to produce seizures. Harmane (2.5, 5.0, or 10 mg/kg intraperitoneally) increased the threshold of seizures in MES dose-dependently. The convulsions produced by PTZ were decreased by the low dose of harmane (2.5 mg/kg), but the high dose of harmane (10 mg/kg) resulted in worse grade V convulsions followed by more lethality compared with PTZ alone. Therefore, harmane seems to be protective against grand mal seizures in the MES model but not against a petit mal seizure model (PTZ) in mice. |
| Databáze: | OpenAIRE |
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