Neural correlates of high and craving during cocaine self-administration using BOLD fMRI
| Autor: | Thomas J. Ross, Alan S. Bloom, Betty Jo Salmeron, Robert C. Risinger, Elliot A. Stein, Raymond G. Hoffmann, Hugh Garavan, Michael Sanfilipo, Shelley L. Amen |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cognitive Neuroscience Self Administration Craving Nucleus accumbens Cocaine-Related Disorders Reward system Cocaine Dopamine Uptake Inhibitors Neuroimaging Image Interpretation Computer-Assisted medicine Humans Behavior Neural correlates of consciousness medicine.diagnostic_test Hemodynamics Brain medicine.disease Magnetic Resonance Imaging Oxygen Substance abuse Neurology medicine.symptom Self-administration Functional magnetic resonance imaging Psychology Neuroscience |
| Zdroj: | NeuroImage. 26:1097-1108 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2005.03.030 |
| Popis: | Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system. |
| Databáze: | OpenAIRE |
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