Alloreactive Immune Response Associated to Human Mesenchymal Stromal Cells Treatment: A Systematic Review

Autor: Salvador Arias-Santiago, Álvaro Sierra-Sánchez, Trinidad Montero-Vilchez, A. Fernández-González, Raquel Sanabria-de la Torre, María I Quiñones-Vico, Manuel Sánchez-Díaz
Rok vydání: 2021
Předmět:
Zdroj: Digibug. Repositorio Institucional de la Universidad de Granada
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Journal of Clinical Medicine, Vol 10, Iss 2991, p 2991 (2021)
Journal of Clinical Medicine
ISSN: 2077-0383
Popis: This research has received competitive funding in the call for grants for the financing of Research, Development and Innovation in Biomedicine and Health Sciences in Andalusia, for the year 2019 (PIGE-0247-2019; PIGE-0242-2019).
The well-known immunomodulatory and regenerative properties of mesenchymal stromal cells (MSCs) are the reason why they are being used for the treatment of many diseases. Because they are considered hypoimmunogenic, MSCs treatments are performed without considering histocompatibility barriers and without anticipating possible immune rejections. However, recent preclinical studies describe the generation of alloantibodies and the immune rejection of MSCs. This has led to an increasing number of clinical trials evaluating the immunological profile of patients after treatment with MSCs. The objective of this systematic review was to evaluate the generation of donor specific antibodies (DSA) after allogeneic MSC (allo-MSC) therapy and the impact on safety or tolerability. Data from 555 patients were included in the systematic review, 356 were treated with allo-MSC and the rest were treated with placebo or control drugs. A mean of 11.51% of allo-MSC-treated patients developed DSA. Specifically, 14.95% of these patients developed DSA and 6.33% of them developed cPRA. Neither the production of DSA after treatment nor the presence of DSA at baseline (presensitization) were correlated with safety and/or tolerability of the treatment. The number of doses administrated and human leucocyte antigen (HLA) mismatches between donor and recipient did not affect the production of DSA. The safety of allo-MSC therapy has been proved in all the studies and the generation of alloantibodies might not have clinical relevance. However, there are very few studies in the area. More studies with adequate designs are needed to confirm these results.
Research, Development and Innovation in Biomedicine and Health Sciences in Andalusia PIGE-0247-2019 PIGE-0242-2019
Databáze: OpenAIRE
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