Influenza A Virus M2 Protein: Roles from Ingress to Egress
Autor: | Rashid Manzoor, Ayato Takada, Manabu Igarashi |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Virus Integration Cellular homeostasis medicine.disease_cause influenza A virus M2 protein pathogenicity Interactome Catalysis Article Influenza virus matrix protein 2 Inorganic Chemistry Viral Matrix Proteins lcsh:Chemistry 03 medical and health sciences Influenza A virus medicine Protein biosynthesis Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Ion channel Virus Release Chemistry Organic Chemistry General Medicine Computer Science Applications Cell biology 030104 developmental biology Viral replication Ion channel activity lcsh:Biology (General) lcsh:QD1-999 Protein Processing Post-Translational |
Zdroj: | International Journal of Molecular Sciences, Vol 18, Iss 12, p 2649 (2017) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2649 |
ISSN: | 1422-0067 |
Popis: | Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeostasis in a variety of ways. It is also the target for ion channel inhibitors, i.e., anti-influenza drugs. Thus far, several studies have been conducted to elucidate its biophysical characteristics, structure-function relationships of the ion channel, and the M2-host interactome. In this review, we discuss M2 protein synthesis and assembly into an ion channel, its roles in IAV replication, and the pathophysiological impact on the host cell. |
Databáze: | OpenAIRE |
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