Involvement of Lipoproteins in Suppression of Interleukin 2-Dependent Cell Proliferation by Sera from Aged Humans
| Autor: | Seishi Nagano, Tsutomu Hirano, Yoshihiko Ohtsuka, Terumi Takahashi, Kazuo Kobayashi, Seiichi Furukawa |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Interleukin 2 Aging medicine.medical_specialty Very low-density lipoprotein medicine.medical_treatment Dose-Response Relationship Immunologic Lipoproteins VLDL Biology Lymphocyte Activation Cell Line chemistry.chemical_compound Immune system Internal medicine medicine Humans Aged Aged 80 and over Cholesterol Cell growth Interleukin T-Lymphocytes Helper-Inducer Lipids Lipoproteins LDL Apolipoproteins Endocrinology Cytokine chemistry Immunology Interleukin-2 lipids (amino acids peptides and proteins) Geriatrics and Gerontology T-Lymphocytes Cytotoxic medicine.drug Lipoprotein |
| Zdroj: | Gerontology. 36:268-275 |
| ISSN: | 1423-0003 0304-324X |
| DOI: | 10.1159/000213211 |
| Popis: | Sera from the elderly, but not young, inhibited markedly interleukin 2 (IL-2)-dependent proliferation of cloned T cells. Sera of aged humans contained high levels of tri-glyceride, cholesterol, very low density lipoproteins (VLDL) and low density lipoproteins (LDL). VLDL and LDL inhibited the proliferation in a dose-related manner. The inhibition correlated with levels of serum VLDL and LDL. These results suggest that lipoproteins may act as a regulator of IL-2-dependent proliferation and that disturbance of lipid and lipoprotein metabolism may be partially responsible for diminished immune responses in the elderly. |
| Databáze: | OpenAIRE |
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