Sublethal effects of microcystin-LR in the exposure and depuration time in a neotropical fish: Multibiomarker approach
| Autor: | Sabrina Loise de Morais Calado, Valéria F. Magalhães, Helena Cristina Silva de Assis, Gustavo Souza Santos, Maritana Mela, Lucila Andriani Coral, Marta Margarete Cestari, Ana Pelanda, Maiara Vicentini, Hayanna Karla Felipe Santos |
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| Rok vydání: | 2019 |
| Předmět: |
Gill
Gills Antioxidant Microcystins Metabolic Clearance Rate Health Toxicology and Mutagenesis medicine.medical_treatment 0211 other engineering and technologies Physiology Microcystin-LR 02 engineering and technology 010501 environmental sciences Biology medicine.disease_cause 01 natural sciences Antioxidants chemistry.chemical_compound Geophagus medicine Bioassay Animals Gonads 0105 earth and related environmental sciences 021110 strategic defence & security studies Dose-Response Relationship Drug Toxin Public Health Environmental and Occupational Health General Medicine Cichlids Eutrophication biology.organism_classification Pollution chemistry Liver Seafood Organ Specificity Neotropical fish Marine Toxins Biomarkers Water Pollutants Chemical |
| Zdroj: | Ecotoxicology and environmental safety. 183 |
| ISSN: | 1090-2414 |
| Popis: | Eutrophication is an ecological process that results in cyanobacterial blooms. Microcystin-LR is the most toxic variant of microcystins and may cause toxic effects in the organisms, mainly in hepatic tissues. The aims of this study were to use multiple biomarkers in order to evaluate the sublethal effects of a low concentration of MC-LR (1 μg/L) in fish Geophagus brasiliensis by waterborne exposure; and evaluate the depuration of this toxin during 15 days. A group of 30 fish was exposed to 1 μg/L of MC-LR solution for 96 h in a static bioassay. After this time, blood, brain, muscle, liver, gonad and gills were collected from half of the exposed fish group in order to evaluate chemical, biochemical, histological and genotoxic biomarkers. The rest of the fish group was submitted to the depuration experiment with free MC-LR water for 15 days. After this time the same tissues were collected and evaluated using biomarkers analysis. Toxic effects were found mostly in the fish liver from depuration time as alterations on the antioxidant system and histopathologies. The results showed that even low concentrations can cause sublethal effects to aquatic organisms, and cyanotoxins monitoring and regulation tools are required. |
| Databáze: | OpenAIRE |
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