Prophylactic Use of Apraclonidine for Intraocular Pressure Increase After Nd:YAG Capsulotomies
| Autor: | Kenneth W. Olander, Robert B. Taylor, Linda L. Burk, David E. Silverstone, Stephen F. Brint, George R. McCarty, Joseph M. deFaller |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Intraocular pressure genetic structures medicine.medical_treatment Eye disease Lens Capsule Crystalline Ocular hypertension Cataract Extraction Clonidine Placebos Postoperative Complications Double-Blind Method medicine Humans Posterior Capsulotomy Intraocular Pressure Aged Chemotherapy business.industry Incidence medicine.disease Ophthalmology Treatment Outcome Anesthesia Capsulotomy Female Premedication Laser Therapy Apraclonidine business Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 113:401-405 |
| ISSN: | 0002-9394 |
| Popis: | We evaluated the prophylactic effect of 1% apraclonidine HCl in controlling the increase in intraocular pressure after Nd:YAG posterior capsulotomy in a large, multicenter double-masked clinical trial. One hundred sixty-four patients were enrolled into the apraclonidine-treated group, and 165 into the vehicle-treated group. The incidence of increase in intraocular pressure (greater than 5 mm Hg) in the apraclonidine-treated group (7%, 11 of 163 patients) was significantly less than that in the vehicle-treated group (39%, 64 of 164 patients). Similarly, the mean maximal change in intraocular pressure in the apraclonidine-treated group (1.3-mm Hg decrease) was significantly different from the increase in the vehicle-treated group (5.3-mm Hg increase). Few adverse reactions were observed. The risk for significant loss of visual function after Nd:YAG laser posterior capsulotomy, combined with the efficacy and relative safety of prophylactic apraclonidine, suggest its addition to the treatment armamentarium. |
| Databáze: | OpenAIRE |
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