Cortical neuronal cytoskeletal changes associated with FIV infection
| Autor: | Oscar Prospéro-García, John H. Elder, Steven J. Henriksen, Howard S. Fox, Warren G. Young, Stanley Jacobson, Tom R. Phillips, Floyd E. Bloom |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pathology
medicine.medical_specialty Feline immunodeficiency virus Central nervous system HIV Infections Immunodeficiency Virus Feline Biology Cellular and Molecular Neuroscience Immune system Feline Acquired Immunodeficiency Syndrome Virology medicine Animals Cytoskeleton Immunodeficiency Cerebral Cortex Neurons Dementia pugilistica Motor neuron medicine.disease biology.organism_classification Frontal Lobe Disease Models Animal medicine.anatomical_structure Neurology Cerebral cortex Immunology Cats Female Neurology (clinical) Neuron |
| Zdroj: | Journal of Neurovirology. 3:283-289 |
| ISSN: | 1538-2443 1355-0284 |
| DOI: | 10.3109/13550289709029469 |
| Popis: | HIV-1 infection is often complicated by central nervous system (CNS) dysfunction. Degenerative neuronal changes as well as neuronal loss have been documented in individuals with AIDS. Feline immunodeficiency virus (FIV) infection of cats provides a model for both the immune and the central nervous system manifestations of HIV infection of humans. In this study we have examined neurons in the frontal cortex of feline immunodeficiency virus-infected cats and controls for immunoreactivity with SMI 32, an antibody recognizing a non-phosphorylated epitope on neurofilaments. We noted a significant increase in the number of immunoreactive pyramidal cells in infected animals compared to controls. The changes seen in the neuronal cytoskeleton as a consequence of the inoculation with FIV were similar to those seen in humans undergoing the normal aging process as well as those suffering from neurological diseases, including Alzheimer's and dementia pugilistica. The changes we noted in the feline brain were also similar to that reported in animals with traumatic injuries or with spontaneously occurring or induced motor neuron diseases, suggesting that the increase in reactivity represents a deleterious effect of FIV on the central nervous system. |
| Databáze: | OpenAIRE |
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