Lasting metabolic effect of a high-fructose diet on global cerebral ischemia
| Autor: | Oluwatomilayo Patience Ojo, Oluwole B. Akinola, Gloria Patricia Cardona-Gómez, Johanna Gutierrez-Vargas, Paula Andrea Perez-Corredor |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Ischemia Medicine (miscellaneous) Fructose Fructose diet Diet High-Fat Brain Ischemia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metabolic Diseases Adipocyte Internal medicine Hyperlipidemia medicine Animals Obesity cardiovascular diseases Rats Wistar Metabolic Syndrome 030109 nutrition & dietetics Nutrition and Dietetics business.industry General Neuroscience Autophagy General Medicine medicine.disease Diet Rats Endocrinology chemistry Metabolic effects business 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Nutritional Neuroscience. 25:1159-1172 |
| ISSN: | 1476-8305 1028-415X |
| DOI: | 10.1080/1028415x.2020.1841482 |
| Popis: | Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects of a 20% high fructose diet (HFD) and global cerebral ischemia on neurological, cognitive and emotional performance in three-month-old male Wistar rats. Results: Our results demonstrated that fructose intake led to increases in body weight and blood glucose, as well as reduced insulin sensitivity. The co-morbidity of fructose intake and cerebral ischemia resulted to hyperlipidemia, as well as increases in liver and adipocyte damage, which worsened neurological performance and resulted in alterations in learning and emotional skills at two weeks post-ischemia. No significant biochemical changes in autophagy and plasticity markers at the late stage of ischemia were observed. Conclusion: These results suggested that obesity causes a lasting effect on metabolic disorders that can contribute to increased neurological impairment after cerebral ischemia. |
| Databáze: | OpenAIRE |
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