Expression study of candidate miRNAs and evaluation of their potential use as biomarkers of diabetic neuropathy
| Autor: | Cristina Politi, Maria Elena Rinaldi, Davide Lauro, Paola Borgiani, Carla Greco, Giuseppe Novelli, Andrea Latini, Vincenza Spallone, Cinzia D’Amato, Antonella Colantuono, Cinzia Ciccacci |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research medicine.medical_specialty Diabetic neuropathy Type 2 diabetes Biology Candidate mirnas 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Polymorphism (computer science) Internal medicine microRNA Genetics medicine Humans In patient Allele Aged Middle Aged medicine.disease diabetic neuropathy microRNAs 030104 developmental biology Diabetes Mellitus Type 2 Settore MED/03 Female Autonomic neuropathy 030217 neurology & neurosurgery Biomarkers expression study |
| Popis: | Aim: To evaluate the expression of candidate miRNAs in relation to diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN). Materials & methods: The expression of six candidate miRNAs has been evaluated in 49 Type 2 diabetes patients with neurological evaluation. Results: A higher expression of miR-128a was seen in patients with DPN compared with those without DPN (p = 0.015). miR-155 and miR-499a seemed to be down-expressed in patients with DPN (p = 0.04 and p = 0.05, respectively). A lower expression of miR-155 (p = 0.05) was observed even in patients with CAN with respect to CAN-negative. A higher expression of miR-155 was associated with the rs767649 polymorphism variant allele compared with the wild-type allele (p = 0.03). Conclusion: miR-128a, miR-155 and miR-499a might be involved in diabetic neuropathies development. |
| Databáze: | OpenAIRE |
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