Forelimb Deformity of Offspring of Rats Given Dichlorphenamide During Pregnancy
| Autor: | W. M. Layton, D. W. Hallesy |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
medicine.medical_specialty Dichlorphenamide Offspring medicine.drug_class Biology General Biochemistry Genetics and Molecular Biology Fetus Pregnancy Internal medicine Forelimb medicine High doses Deformity Animals Carbonic anhydrase inhibitor Abnormalities Drug-Induced medicine.disease Rats medicine.anatomical_structure Endocrinology Animals Newborn Pregnancy Animal Female medicine.symptom Acetazolamide medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 126:6-8 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-126-32352 |
| Popis: | SummaryAdministration of very high doses of dichlorphenamide, a carbonic anhydrase inhibitor, in the diet of rats during pregnancy is associated with the production, in some of the offspring, of a deformity consisting of a postaxial defect of the right forelimb. This is not associated with any other demonstrable anatomical abnormalities. This deformity appears to be the same as that caused by acetazolamide, a compound of quite different chemical structure which is also a potent carbonic anhydrase inhibitor. |
| Databáze: | OpenAIRE |
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