Foxp3 in control of the regulatory T cell lineage
| Autor: | Ye Zheng, Alexander Y. Rudensky |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Autoimmune disease
Mutation Regulatory T cell T-Lymphocytes Immunology FOXP3 Forkhead Transcription Factors chemical and pharmacologic phenomena Biology medicine.disease medicine.disease_cause T-Lymphocytes Regulatory Autoimmunity medicine.anatomical_structure Immune system medicine Animals Humans Immunology and Allergy Cell Lineage IL-2 receptor Transcription factor |
| Zdroj: | Nature Immunology. 8:457-462 |
| ISSN: | 1529-2916 1529-2908 |
| Popis: | Foxp3, an X chromosome-encoded forkhead transcription factor family member, is indispensable for the differentiation of regulatory T cells. These cells have a vital role in preventing autoimmunity and pathology inflicted by uncontrolled immune responses to infections. Deficiency or mutation in Foxp3 in humans and mice leads to an early onset, highly aggressive and fatal autoimmune disease affecting various tissues. Here, we review recent advances in our understanding of the Foxp3-dependent molecular and functional program and the role of Foxp3 in regulatory T cell biology. |
| Databáze: | OpenAIRE |
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