Augmenting Effect of Rheumatoid Sera in a Streptococcal Haemagglutination Test
| Autor: | H. J. Gibson, N. R. Ling |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
Hemagglutination
biology business.industry Immunology Arthritis Oxidation reduction Hemagglutination Tests Articles medicine.disease General Biochemistry Genetics and Molecular Biology Hemagglutination tests Agglutination (biology) Rheumatology Antigen Rheumatic Diseases Rheumatoid arthritis medicine biology.protein Immunology and Allergy Antibody business Oxidation-Reduction |
| Zdroj: | Annals of the Rheumatic Diseases. 16:111-117 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.16.1.111 |
| Popis: | Culture filtrates ofstreptococci wereshownby Rantz, Randall, andZuckerman (1956) tocontain a polysaccharide whichattached itself toerythrocytes, preparing themforagglutination byhumansera. Thispolysaccharide wasproduced byGram-positive butnotbyGram-negative organisms. Itsdistributionsuggested tousa possible relationship toan unidentified antigen responsible forthemarked agglutination ofstreptococci andcertain other Grampositive organisms byseraofpatients suffering from rheumatoid arthritis (Cecil, Nicholls, andStainsby, 1930;Dawson,Olmstead, andBoots,1932).A possible connexion wasalsosuggested byareport thatserafrompatients suffering fromsomeofthe collagen groupofdiseases showed hightitres inthe streptococcal haemagglutination test(Rantz, 1953). Thetitres increased somewhat withage(Rantz, Zuckerman, andRandall, 1952), butapparently bore no relation to previous streptococcal infection (Rantz, Zuckerman, andRandall, 1952; Harris and Harris, 1953).Theeasewithwhichthis test maybe performed madeitpossible forustoexamine sera fromalarge numberofpatients ofallclinical types. Although higher titres withserafrompatients suffering fromrheumatoid arthritis werenotinvariableorspecific, a tendency tohightitres, which could notbeaccounted foron anagebasis was noted, withoccasional unexplained exceptionally high titres accompanied byastrongly positive RoseWaalertest(Rose, Ragan,Pearce, andLipman, 1948; Waaler, 1940). Toaccount forthis phenomenonitwaspostulated that thehightitres obtained withsuchserawereduetothedualaction ofan antibody anda co-existing augmenting factor. Evidence infavour ofthis hypothesis ispresented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|