Vandetanib therapy in medullary thyroid cancer
| Autor: | Richard P. Baum, John Zaknun, Martin Zeitz, Harshad R. Kulkarni, Patricia Grabowski, Dieter Hörsch, Franziska Briest |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Angiogenesis medicine.drug_class Antineoplastic Agents Vandetanib Proto-Oncogene Mas Tyrosine-kinase inhibitor chemistry.chemical_compound Piperidines Internal medicine Medicine Animals Humans Pharmacology (medical) Drug Interactions Epidermal growth factor receptor Thyroid Neoplasms Adverse effect Protein Kinase Inhibitors Pharmacology biology business.industry Proto-Oncogene Proteins c-ret Medullary thyroid cancer General Medicine medicine.disease Carcinoma Neuroendocrine Vascular endothelial growth factor ErbB Receptors Receptors Vascular Endothelial Growth Factor chemistry biology.protein Quinazolines business medicine.drug Rare disease |
| Zdroj: | Drugs of today (Barcelona, Spain : 1998). 48(11) |
| ISSN: | 1699-3993 |
| Popis: | The U.S. Food and Drug Administration (FDA) approved vandetanib in April 2011 for the treatment of unresectable, locally advanced or metastatic medullary thyroid cancer (MTC). In Europe it was approved in March 2012, but only for the treatment of aggressive and symptomatic MTC. This small molecule is a tyrosine kinase inhibitor of several growth factors involved in cellular proliferation and angiogenesis, including the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptors 2 and 3 (VEGFR-2, VEGFR-3). In addition, vandetanib is an inhibitor of the RET (rearranged during transfection) gene, a proto-oncogene often mutated in familial MTC. Since MTC is a rare disease, for which no previous medical therapies are approved, vandetanib is the first drug shown to be effective in a large phase III trial treating patients with metastatic or locally advanced MTC. Common adverse events are diarrhea, nausea, hypertension, headache and QT prolongation that are manageable and are commonly outweighed by the benefits of vandetanib in terms of delaying disease progression and inducing tumor response. |
| Databáze: | OpenAIRE |
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