Natural SIV Hosts: Showing AIDS the Door
Autor: | Ann Chahroudi, Steven E. Bosinger, Guido Silvestri, Mirko Paiardini, Thomas H. Vanderford |
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Rok vydání: | 2012 |
Předmět: |
CD4-Positive T-Lymphocytes
viruses Simian Acquired Immunodeficiency Syndrome HIV Infections Adaptive Immunity Biology Simian medicine.disease_cause Article Virus Cercocebus atys Acquired immunodeficiency syndrome (AIDS) T-Lymphocyte Subsets Chlorocebus aethiops medicine Animals Humans Immunodeficiency Multidisciplinary Transmission (medicine) virus diseases Simian immunodeficiency virus medicine.disease Acquired immune system biology.organism_classification Virology Immunity Innate Infectious Disease Transmission Vertical Chronic infection Host-Pathogen Interactions Immunology Disease Progression Female Simian Immunodeficiency Virus |
Zdroj: | Science. 335:1188-1193 |
ISSN: | 1095-9203 0036-8075 |
Popis: | Lessons from SIV HIV infection in humans is a chronic infection and, if left untreated, the majority of infected individuals will succumb to AIDS. Many species of African nonhuman primates are chronically infected with simian immunodeficiency virus (SIV); however, in the majority of these species, the animals remain healthy despite the presence of high viral loads. Chahroudi et al. (p. 1188 ) review the underlying immune mechanisms that help protect natural hosts from progressing to AIDS and how these responses differ from what is observed in HIV-infected humans and SIV-infected nonhuman primate species that develop AIDS. |
Databáze: | OpenAIRE |
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