Natural SIV Hosts: Showing AIDS the Door
| Autor: | Ann Chahroudi, Steven E. Bosinger, Guido Silvestri, Mirko Paiardini, Thomas H. Vanderford |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
CD4-Positive T-Lymphocytes
viruses Simian Acquired Immunodeficiency Syndrome HIV Infections Adaptive Immunity Biology Simian medicine.disease_cause Article Virus Cercocebus atys Acquired immunodeficiency syndrome (AIDS) T-Lymphocyte Subsets Chlorocebus aethiops medicine Animals Humans Immunodeficiency Multidisciplinary Transmission (medicine) virus diseases Simian immunodeficiency virus medicine.disease Acquired immune system biology.organism_classification Virology Immunity Innate Infectious Disease Transmission Vertical Chronic infection Host-Pathogen Interactions Immunology Disease Progression Female Simian Immunodeficiency Virus |
| Zdroj: | Science. 335:1188-1193 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Lessons from SIV HIV infection in humans is a chronic infection and, if left untreated, the majority of infected individuals will succumb to AIDS. Many species of African nonhuman primates are chronically infected with simian immunodeficiency virus (SIV); however, in the majority of these species, the animals remain healthy despite the presence of high viral loads. Chahroudi et al. (p. 1188 ) review the underlying immune mechanisms that help protect natural hosts from progressing to AIDS and how these responses differ from what is observed in HIV-infected humans and SIV-infected nonhuman primate species that develop AIDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|