Testing the Chemosensitivity of Renal Carcinoma in vitro
| Autor: | M. O. Symes, P. J. B. Smith, A. V. Kaisary, Teresa Lai, M.A. Ferro |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Medroxyprogesterone Pathology medicine.medical_specialty Urology medicine.medical_treatment Antineoplastic Agents Medroxyprogesterone Acetate Pharmacology Vinblastine In vivo Tumor Cells Cultured medicine Carcinoma Humans Doxorubicin Selenomethionine Aged Kidney Chemotherapy Dose-Response Relationship Drug business.industry Middle Aged medicine.disease Kidney Neoplasms In vitro Neoplasm Proteins Methotrexate medicine.anatomical_structure Female business medicine.drug |
| Zdroj: | British Journal of Urology. 64:25-29 |
| ISSN: | 1464-410X 0007-1331 |
| DOI: | 10.1111/j.1464-410x.1989.tb05517.x |
| Popis: | Tumour cells from 23 renal carcinomas were exposed in vitro to increasing concentrations of medroxyprogesterone acetate (MPA) or one of several cytotoxic agents. Thereafter the uptake of 75Selenomethionine (75SeM) was compared to that of tumour cells not exposed to the drug. Using drug concentrations similar to those seen following in vivo administration in patients, MPA produced greater than or equal to 50% inhibition of 75SeM uptake in 5 of 23 cases. The comparable proportion for doxorubicin was 4 of 5 and for mitozantrone 7 of 12. Methotrexate and Vinblastine were much less effective. In all cases where greater than or equal to 50% inhibition was obtained with doxorubicin and mitozantrone the carcinoma had spread beyond the kidney. Thus drug sensitivity may be associated with a high mitotic rate. |
| Databáze: | OpenAIRE |
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