In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of Moringa oleifera Plants from Rivers State, Niger Delta, Nigeria
| Autor: | IM Siminialayi, Lucky Legbosi Nwidu, Wayne G. Carter, Ekramy Elmorsy, Jonah Sydney Aprioku |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant antioxidant DPPH medicine.medical_treatment Flavonoid lcsh:Medicine anti-cholinesterases Moringa 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine oxidative stress Gallic acid General Environmental Science Moringa oleifera chemistry.chemical_classification Traditional medicine lcsh:R General Engineering Ascorbic acid 030104 developmental biology chemistry visual_art DPPH radical scavenging visual_art.visual_art_medium General Earth and Planetary Sciences Bark Quercetin Alzheimer’s disease 030217 neurology & neurosurgery |
| Zdroj: | Medicines Volume 5 Issue 3 Medicines, Vol 5, Iss 3, p 71 (2018) |
| ISSN: | 2305-6320 |
| DOI: | 10.3390/medicines5030071 |
| Popis: | This study evaluated Moringa oleifera extracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts of Moringa oleifera were evaluated for inhibition of acetylcholinesterase (AChE) activity, antioxidant properties, and total phenolic and flavonoid contents using standard procedures. M. oleifera extracts possessed significant and concentration dependent AChE inhibitory activity for methanolic, aqueous, and ethanolic extracts. For the most potent extracts, the percentage AChE inhibition/IC50 (µ g/mL) values were Moringa oleifera root methanolic extracts (MORME): ~80%/0.00845 Moringa oleifera root ethanolic extract 1 (MOREE1): ~90%/0.0563 Moringa oleifera root ethanolic extract 2 (MOREE2): ~70%/0.00175 and Moringa oleifera bark ethanolic extract (MOBEE): ~70%/0.0173. The descending order of AChE inhibitory potency of plant parts were: root > bark > leaf > flowers > seed. All M. oleifera methanolic extracts at a concentration of 1000 µ g/mL displayed significant (p < 0.05&ndash 0.001) DPPH radical scavenging activity, with values of ~20&ndash 50% of that of ascorbic acid. The total phenolic content and total flavonoid content (TPC/TFC) of MORME, Moringa Oju bark methanolic extract (MOBME), MOREE1, MOREE2 and Moringa leaf ethanolic leaf extract (MLEE) were (287/254), (212/113), (223/185), (203/343) and (201/102) mg gallic acid equivalents/g and quercetin equivalents/g, respectively. There was an inverse correlation between plant extract AChE inhibition and total phenolic (p < 0.0001) and total flavonoid contents (p < 0.0012). In summary, this study revealed 5 of 19 extracts of M. oleifera that have potent in vitro anti-cholinesterase and antioxidant activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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