Increased oxidative stress in subjects exposed to carbon disulfide (CS2)--an occupational coronary risk factor
| Autor: | Jerzy-Roch Nofer, Julita Chojnowska-Jezierska, Justyna M Wisniewska-Knypl, Tadeusz Hałatek, Teresa Wrońska-Nofer |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Arteriosclerosis Health Toxicology and Mutagenesis medicine.medical_treatment alpha-Tocopherol Oxidative phosphorylation Toxicology medicine.disease_cause Thiobarbituric Acid Reactive Substances Lipid peroxidation chemistry.chemical_compound Risk Factors Internal medicine Occupational Exposure parasitic diseases TBARS Medicine Humans Glutathione Peroxidase biology business.industry General Medicine Glutathione Middle Aged Catalase Oxidative Stress Endocrinology chemistry Carbon Disulfide Toxicity Epidemiological Monitoring biology.protein Poland business Oxidative stress Environmental Monitoring |
| Zdroj: | Archives of toxicology. 76(3) |
| ISSN: | 0340-5761 |
| Popis: | There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies the oxidative status of plasma, which is a major determinant of the susceptibility to atherosclerosis. Concentrations of thiobarbituric reactive substances (TBARS), which reflect lipid peroxidation processes in plasma, were determined in 29 men who were exposed to CS2 for more than 20 years, in 24 patients with peripheral atherosclerosis, and in 30 unexposed, healthy control subjects. TBARS concentrations were significantly increased both in CS2-exposed subjects and in patients with peripheral atherosclerosis. Subjects in both groups presented also with decreased levels of plasma alpha-tocopherol, a major plasma antioxidant. In addition, decreased activities of two enzymatic antioxidants, glutathion peroxidase and catalase, were noted both in CS2-exposed subjects and patients with peripheral atherosclerosis. Finally, LDL isolated from both groups showed increased susceptibility to transition metal-induced oxidation in vitro. It is concluded, that occupational exposure to CS2 produces oxidative stress in plasma. This may favor the development of atherosclerosis and increase the incidence of CHD in workers exposed to CS2. |
| Databáze: | OpenAIRE |
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