Carboxylate directed cross-coupling reactions in the synthesis of trisubstituted benzoic acids

Autor:	Renmao Liu, Jason G. Chen, Martine Canters, Ulrike Nettekoven, Changkang Huang, Ioannis N. Houpis
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Base (chemistry) Organic Chemistry Appropriate use Biochemistry Combinatorial chemistry Coupling reaction Solvent chemistry.chemical_compound chemistry Yield (chemistry) Organic chemistry Carboxylate Physical and Theoretical Chemistry Selectivity Phosphine
Zdroj:	Organic letters. 10(24)
ISSN:	1523-7052
Popis:	The carboxylate anion has been used as a directing group to effect selective ortho-substituted derivatives 3 (>99:1 selectivity 50−80% yield). The solvent, base, and equivalents of base are the determining factors for the success of this reaction. The directing effect can be reversed by the appropriate use of phosphine ligands to prepare the para-substituted 4 selectively (ca. 12:1 selectivity).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4eacb1ed4f7c02af9dd1c81b49a20ab https://pubmed.ncbi.nlm.nih.gov/19053734 Zobrazit plný text záznamu