Nanometer ultrastructural brain damage following low intensity primary blast wave exposure
| Autor: | Ralph G. DePalma, Catherine E. Johnson, Hailong Song, Landry M. Konan, Graham K. Hubler, Jiankun Cui, Zezong Gu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
blast physics
primary blast wave Traumatic brain injury Review Brain damage mild traumatic brain injury open-field blast animal model ultrastructural abnormalities behavior lcsh:RC346-429 Blast injury 03 medical and health sciences 0302 clinical medicine Animal model Developmental Neuroscience hemic and lymphatic diseases Concussion medicine 030212 general & internal medicine lcsh:Neurology. Diseases of the nervous system Blast wave business.industry medicine.disease Murine model Blast effects medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, Vol 13, Iss 9, Pp 1516-1519 (2018) |
| ISSN: | 1673-5374 |
| Popis: | Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast mediated pathophysiology upon later neurobehavioral disorders has been controversial. Developing a military preclinical blast model to simulate the pathophysiology of human blast injury is an important first step. This article provides an overview of primary blast effects and perspectives of our recent studies demonstrating ultrastructural changes in the brain and behavioral disorders resulting from open-field blast exposures up to 46.6 kPa using a murine model. The model is scalable and permits exposure to varying magnitudes of primary blast injuries by placing animals at different distances from the blast center or by changing the amount of C4 charge. We here review the implications and future applications and directions of using this animal model to uncover the underlying mechanisms related to primary blast injury. Overall, these studies offer the prospect of enhanced understanding of the pathogenesis of primary low-intensity blast-induced TBI and insights for prevention, diagnosis and treatment of blast induced TBI, particularly mTBI/concussion related to current combat exposures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|