Effect of the Portacaval Shunt on Reperfusion Injury after 65% Hepatectomy in Pigs
| Autor: | Ioanna Andreadou, T. Sidiropoulou, K. Katis, Charalampos Farantos, I. Skalkidis, Agathi Paphiti, K. Dimopoulou, Nikolaos Arkadopoulos, V Smyrniotis, Georgia Kostopanagiotou, K. Tzavara, E. Hatzoudi, Kassiani Theodoraki |
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| Rok vydání: | 2008 |
| Předmět: |
Portacaval Shunt
Surgical Swine business.industry medicine.medical_treatment Portacaval Ischemia Portacaval shunt Liver transplantation medicine.disease Liver regeneration Random Allocation Liver Reperfusion Injury Anesthesia Animals Hepatectomy Medicine Surgery Warm Ischemia business Reperfusion injury Shunt (electrical) |
| Zdroj: | European Surgical Research. 40:347-353 |
| ISSN: | 1421-9921 0014-312X |
| Popis: | Background: Portal flow diversion by portacaval shunts (PCS) has been shown to prevent primary graft nonfunction in liver transplantation using small-for-size grafts. In this study, we examine whether PCS can improve reperfusion injury after major hepatectomy in pigs. Materials and Methods: In 14 pigs, a partial PCS was constructed following 65% hepatectomy and 1 h of inflow ischemia. During 24 h of reperfusion, the shunt was either closed (group A, n = 7) or left open (group B, n = 7). Results: 24 h after reperfusion, group A had higher levels of alanine aminotransferase (70 ± 12 IU/l vs. 51 ± 5.9 IU/l; p < 0.05), alanine aminotransferase per gram of liver remnant (0.41 ± 0.07 IU/l/g vs. 0.21 ± 0.05 IU/l/g; p < 0.05), prothrombin time (24.1 ± 2.4 s vs. 14.3 ± 2.9 s; p < 0.05), international normalized ratio (2.11 ± 0.15 vs. 1.29 ± 0.28; p < 0.05), hepatocyte necrosis scores and percentages of nuclei stained for proliferating cell nuclear antigen (52.57 ± 8.9% vs. 36.71 ± 6%; p < 0.05) compared to group B. Conclusions: Partial portal flow diversion appears to attenuate reperfusion injury in a porcine model of major hepatectomy. |
| Databáze: | OpenAIRE |
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