| Autor: |
Yalong Xie, Dunfeng Du, Limin Zhang, Yang Yang, Zhimiao Zou, Zeyang Li, Liang Zhou, Runshi Shang, Ping Zhou |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Chemico-biological interactions. 354 |
| ISSN: |
1872-7786 |
| Popis: |
Liver fibrosis is the result of most chronic inflammatory liver damage and seriously endangers human health. However, no drugs have been approved to treat this disease. Previous studies showed that the Toll-like receptors (TLRs)/myeloid differentiation factor-88 (MyD88)/nuclear factor-κB (NF-κB) pathway plays a key role in liver fibrosis. TJ-M2010-5 is a self-developed small molecule MyD88 inhibitor, which has been proven to have a good protective effect in a variety of inflammatory disease models. In the present study, to investigate the anti-fibrotic effect of TJ-M2010-5, mice were injected with carbon tetrachloride (CCl |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect