A Robust Model for Circadian Redox Oscillations
Autor: | Hanspeter Herzel, Achim Kramer, Marta del Olmo |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Circadian clock
Endogeny Mitochondrion Redox fast vs. slow reactions Article lcsh:Chemistry Circadian Clocks Negative feedback Animals Humans Computer Simulation Circadian rhythm ddc:610 lcsh:QH301-705.5 Slow reactions Chemistry mathematical modeling Peroxiredoxins negative feedback Models Theoretical Circadian Rhythm Cell biology switches Sulfiredoxin lcsh:Biology (General) lcsh:QD1-999 redox oscillations 610 Medizin und Gesundheit phases Oxidation-Reduction 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit Signal Transduction |
Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 9, p 2368 (2019) International Journal of Molecular Sciences Volume 20 Issue 9 |
ISSN: | 1422-0067 |
Popis: | The circadian clock is an endogenous oscillator that controls daily rhythms in metabolism, physiology, and behavior. Although the timekeeping components differ among species, a common design principle is a transcription-translation negative feedback loop. However, it is becoming clear that other mechanisms can contribute to the generation of 24 h rhythms. Peroxiredoxins (Prxs) exhibit 24 h rhythms in their redox state in all kingdoms of life. In mammalian adrenal gland, heart and brown adipose tissue, such rhythms are generated as a result of an inactivating hyperoxidation reaction that is reduced by coordinated import of sulfiredoxin (Srx) into the mitochondria. However, a quantitative description of the Prx/Srx oscillating system is still missing. We investigate the basic principles that generate mitochondrial Prx/Srx rhythms using computational modeling. We observe that the previously described delay in mitochondrial Srx import, in combination with an appropriate separation of fast and slow reactions, is sufficient to generate robust self-sustained relaxation-like oscillations. We find that our conceptual model can be regarded as a series of three consecutive phases and two temporal switches, highlighting the importance of delayed negative feedback and switches in the generation of oscillations. Deutsche Forschungsgemeinschaft |
Databáze: | OpenAIRE |
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