Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation

Autor: Jianhui Zhong, Xiang Kong, Hui Juan Chen, Akos Varga-Szemes, Virginia W. Lesslie, Guangming Lu, Jiqiu Wen, U. Joseph Schoepf, Long Jiang Zhang, Yun Fei Wang, Rongfeng Qi, Qiang Xu, Xue Li, Zhe Zhang
Rok vydání: 2017
Předmět:
Male
Auditory Pathways
Time Factors
Epidemiology
030232 urology & nephrology
Neuropsychological Tests
Critical Care and Intensive Care Medicine
Executive Function
0302 clinical medicine
Cognition
Attention
Prospective Studies
Kidney transplantation
Default mode network
medicine.diagnostic_test
Neuropsychology
Brain
Middle Aged
Magnetic Resonance Imaging
Treatment Outcome
Nephrology
Cardiology
Auditory Perception
Visual Perception
Female
Adult
medicine.medical_specialty
Motor Activity
Efferent Pathways
End stage renal disease
03 medical and health sciences
Young Adult
Internal medicine
Task-positive network
medicine
Humans
Visual Pathways
Transplantation
business.industry
Magnetic resonance imaging
Recovery of Function
medicine.disease
Kidney Transplantation
Expressions of Concern
Case-Control Studies
Kidney Failure
Chronic
Nerve Net
business
Functional magnetic resonance imaging
Cognition Disorders
030217 neurology & neurosurgery
Zdroj: Clinical journal of the American Society of Nephrology : CJASN. 13(1)
ISSN: 1555-905X
Popis: Background and objectives Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation. Design, setting, participants, & measurements Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging. Patients were imaged before and 1 and 6 months after kidney transplantation. Functional connectivity of seven resting-state subnetworks was evaluated: default mode network, dorsal attention network, central executive network, self-referential network, sensorimotor network, visual network, and auditory network. Mixed effects models tested associations of ESRD, kidney transplantation, and neuropsychological measurements with functional connectivity. Results Compared with controls, pretransplant patients showed abnormal functional connectivity in six subnetworks. Compared with pretransplant patients, increased functional connectivity was observed in the default mode network, the dorsal attention network, the central executive network, the sensorimotor network, the auditory network, and the visual network 1 and 6 months after kidney transplantation (P=0.01). Six months after kidney transplantation, no significant difference in functional connectivity was observed for the dorsal attention network, the central executive network, the auditory network, or the visual network between patients and controls. Default mode network and sensorimotor network remained significantly different from those in controls when assessed 6 months after kidney transplantation. A relationship between functional connectivity and neuropsychological measurements was found in specific brain regions of some brain networks. Conclusions The recovery patterns of resting-state subnetworks vary after kidney transplantation. The dorsal attention network, the central executive network, the auditory network, and the visual network recovered to normal levels, whereas the default mode network and the sensorimotor network did not recover completely 6 months after kidney transplantation. Neural resting-state functional connectivity was lower among patients with ESRD compared with control subjects, but it significantly improved with kidney transplantation. Resting-state subnetworks exhibited variable recovery, in some cases to levels that were no longer significantly different from those of normal controls.
Databáze: OpenAIRE
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