Differential Prognostic Impact of uPA and PAI-1 in Colon and Rectal Cancer
| Autor: | Svante Nordgren, Marie-Louise Ivarsson, Peter Falk, Marcus Langenskiöld, Eva Angenete, Lena Holmdahl |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Colorectal cancer Protein expression Cohort Studies Extracellular matrix Tumour tissue Plasminogen Activator Inhibitor 1 Humans Medicine Intestinal Mucosa Survival rate Survival analysis Aged Neoplasm Staging Aged 80 and over Rectal Neoplasms business.industry Urokinase Plasminogen Activator General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Urokinase-Type Plasminogen Activator Survival Rate Colonic Neoplasms Cancer research Female Neoplasm staging business |
| Zdroj: | Tumor Biology. 30:210-220 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1159/000239796 |
| Popis: | Degradation of extracellular matrix is important for tumour growth and invasion, which in part is regulated by the plasminogen activation system. The aim of the study was to evaluate the protein expression of urokinase plasminogen activator (uPA) and plasminogen-activating inhibitor-1 (PAI-1) in plasma, tumour-free mucosa and tumour tissue regarding their prognostic value in colon and rectal cancer.Patients (n = 221) undergoing surgery for colorectal cancer were prospectively included. Samples were assayed by ELISA technique.PAI-1 in tumour tissue (p = 0.006), plasma (0.0001) and uPA in tumour-free mucosa (p = 0.006) were associated with survival in rectal cancer in univariate analysis. An uPA expression level below 1.1 ng/mg (log rank test, p0.0001) in tumour-free mucosa was associated with poor survival in rectal cancer. This was true also for patients without disseminated disease (M(0), p = 0.02). PAI-1 in plasma correlated with metastatic disease (p0.0001). uPA and PAI-1 were not associated with survival in either tumour tissue, mucosa or plasma in patients with colon cancer.uPA and PAI-1 have a differential prognostic impact in colon and rectal cancer. Preoperative mucosal uPA and plasma PAI-1 protein expression could possibly be used as prognostic factors in rectal cancer. |
| Databáze: | OpenAIRE |
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