Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from Lepisanthes rubiginosa, a mangrove plant collected from Thua Thien-Hue province, Vietnam

Autor:	Anh Ngoc Ho, Thao Thi Phuong Tran, Viet Cong Do, Chien Van Tran, Loc Van Tran, Van Sung Tran, Nhu Thi Quynh Vo, Luu Nguyen Thi, Ninh Pham Thi
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Traditional medicine Organic Chemistry Glycoside Plant Science Biology Biochemistry Lepisanthes rubiginosa Analytical Chemistry chemistry.chemical_compound chemistry Phytochemical Mangrove Oleanane
Zdroj:	Natural Product Research. 36:1774-1780
ISSN:	1478-6427 1478-6419
DOI:	10.1080/14786419.2020.1817010
Popis:	Phytochemical investigation of the leaves of Lepisanthes rubiginosa led to the isolation of two new glycosides, lepisantheside A (1) and lepisantheside B (2), together with two known compounds acutoside A (3) and 3-O-[β-D-xylopyranosyl-(1→3)-β-D-glucopyranosyl-]-oleanolic acid (4). Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds 1–4 against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated. Compound 4 exhibited significant activity with IC50 values of 9.57, 6.66, 6.97 and 18.32 µM, respectively, in comparison with the postive control ellipticine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e1f31c78cd184c09a66ac884868c45 https://doi.org/10.1080/14786419.2020.1817010 Zobrazit plný text záznamu