COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor
| Autor: | Aya Karam, Thierry Roumeguere, Georges Mjaess, Simone Albisinni, Fouad Aoun |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology medicine.medical_specialty Antineoplastic Agents Hormonal Urology Pneumonia Viral 030232 urology & nephrology Disease Peptidyl-Dipeptidase A medicine.disease_cause TMPRSS2 Article Renin-Angiotensin System Androgen deprivation therapy Betacoronavirus 03 medical and health sciences Prostate cancer 0302 clinical medicine Semen androgen receptor Internal medicine medicine Humans Sex Distribution Pandemics Coronavirus Infectivity SARS-CoV-2 business.industry Serine Endopeptidases Prostatic Neoplasms COVID-19 Androgen Antagonists Virus Internalization Type II Transmembrane Serine Protease medicine.disease Pathophysiology Androgen receptor Gene Expression Regulation Organ Specificity Receptors Androgen Spike Glycoprotein Coronavirus Androgens Receptors Virus Disease Susceptibility Angiotensin-Converting Enzyme 2 Coronavirus Infections business |
| Zdroj: | Progres En Urologie Progrès en Urologie |
| ISSN: | 1166-7087 |
| Popis: | COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy. |
| Databáze: | OpenAIRE |
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