Atypical Pathogen Infection in Adults with Acute Exacerbation of Bronchial Asthma
| Autor: | Maureen G. Friedman, Miriam Ben-Yaakov, Devora Lieberman, Ida Boldur, Bella Ohana, Maija Leinonen, Bella Dvoskin, David Lieberman, Z. Lazarovich, Shmuel Printz |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Mycoplasma pneumoniae Adolescent Exacerbation Critical Care and Intensive Care Medicine medicine.disease_cause Serology Streptococcal Infections Pneumonia Mycoplasma medicine Humans Prospective Studies Respiratory Tract Infections Aged Asthma Chlamydia business.industry Respiratory disease Middle Aged medicine.disease respiratory tract diseases Pneumonia Acute Disease Immunology Respiratory virus Female business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 167:406-410 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200209-996oc |
| Popis: | In a serologically based prospective study, acute infections with four atypical pathogens were determined in 100 adults hospitalized for acute exacerbation of bronchial asthma, and compared with the corresponding rate in a matched control group. Paired sera were tested using immunofluorescence or enzyme immunoassay methods to establish the serologic diagnosis. In 18 patients (18%), there was evidence of acute infection with Mycoplasma pneumoniae, compared with 3% in the control group (p = 0.0006). In 10 of these patients there was evidence of infection with at least one additional pathogen, a respiratory virus in 7. There was no significant difference between the study groups in the rates of acute infection by Chlamydia pneumoniae (8% in the hospitalized patients versus 6% in the control subjects), Legionella spp. (5 versus 3%, respectively), or Coxiella burnettii (no patients in either group). We conclude that of these four atypical pathogens, only infection with M. pneumoniae is associated with hospitalization for acute exacerbation of bronchial asthma. In most of these M. pneumoniae patients there is evidence of infection with a respiratory virus as well. The pathophysiologic and therapeutic significance of these findings should be tested in further studies specifically designed to address these questions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|