Bromofluorination of unsaturated compounds using DMPU/HF as a fluorinating reagent
| Autor: | Bo Xu, Shengzong Liang, Francis J. Barrios, Otome E. Okoromoba, Zofia Hetman, Gerald B. Hammond |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Markovnikov's rule Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry Article 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound DMPU chemistry Reagent Environmental Chemistry Organic chemistry Molecule Reactivity (chemistry) Physical and Theoretical Chemistry N-Bromosuccinimide |
| Zdroj: | Journal of Fluorine Chemistry. 203:136-139 |
| ISSN: | 0022-1139 |
| DOI: | 10.1016/j.jfluchem.2017.07.016 |
| Popis: | Bromofluorination reactions were performed by treating of a variety of unsaturated compounds with N-bromosuccinimide (NBS) and DMPU/HF as the fluorinating reagent. The DMPU/HF complex showed to be an efficient fluorinating reagent to convert alkenes into their corresponding bromofluoro compounds. It showed to have high reactivity and the process afforded bromofluorinated products with good Markovnikov regioselectivity. These fluorinated compounds are useful starting materials and serve as building blocks for many fluorinated biologically active molecules. |
| Databáze: | OpenAIRE |
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