CEACAMs : their role in physiology and pathophysiology
| Autor: | Stefan Pils, Katharina Kuespert, Christof R. Hauck |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Neovascularization
Physiologic Biology Article Animals Genetically Modified Evolution Molecular Neovascularization Antigens CD In vivo Neoplasms ddc:570 medicine Animals Humans Insulin Protein Isoforms Receptor chemistry.chemical_classification Bacteria Cell adhesion molecule Cell Biology Reverse genetics Pathophysiology Carcinoembryonic Antigen Cell biology chemistry Viruses medicine.symptom Glycoprotein Cell Adhesion Molecules Homeostasis |
| Zdroj: | Current Opinion in Cell Biology |
| Popis: | Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo. |
| Databáze: | OpenAIRE |
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