Association of clinicopathological features with E-cadherin (CDH1) gene-160 C > A promoter polymorphism in Turkish colorectal cancer patients
| Autor: | Mehmet Ali Korpinar, Metin Budak, Fumio Shimamoto, Anzel Bahadir, Handan Tuncel, Sibel Erdamar, Gokalp Eral |
|---|---|
| Přispěvatelé: | İÜC, Cerrahpaşa Tıp Fakültesi, Temel Tıp Bilimleri Bölümü |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Male Turkey Colorectal cancer Disease polymerase chain reaction-restriction fragment length polymorphism analysis E-cadherin (CDH1)-160 C > A polymorphism susceptibility CDH1 0302 clinical medicine Gene Frequency Genotype Promoter Regions Genetic biology General Medicine Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cadherins medicine.anatomical_structure 030220 oncology & carcinogenesis Disease Progression Female Colorectal Neoplasms medicine.medical_specialty Colon Rectum colorectal cancer lcsh:RC254-282 Polymorphism Single Nucleotide 03 medical and health sciences Antigens CD Internal medicine Genetic predisposition medicine Humans Radiology Nuclear Medicine and imaging Genetic Predisposition to Disease Allele frequency Aged Retrospective Studies Cadherin business.industry medicine.disease E-cadherin (CDH1)-160 C>A polymorphism 030104 developmental biology Case-Control Studies biology.protein business Clinicopathological features |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 15, Iss 1, Pp 26-31 (2019) |
| Popis: | WOS:000461542500005 PubMed ID: 30880750 Background and Aim of Study: The role of E-cadherin (CDH1) gene-160 C>A (rsl 6260) promoter polymorphism in colorectal cancer (CRC) still remains inconclusive. The aim of this study is to investigate the associations between the CDH1 -160 C>A polymorphism with the susceptibility and clinicopathological development of CRC in the Turkish patients. To our knowledge, this is the first report examining the role of CDH1 polymorphism in Turkish CRC patients. Materials and Methods: A total of 92 colorectal carcinoma cases (including 62 colon and 30 rectal cancer patients) and the corresponding adjacent normal tissues as controls were studied. The polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. Clinicopathological features including patient's age, gender, tumor stage, and tumor location (colon/ rectum) were compared statistically with the polymorphism status. Results: There was no significant difference in both genotype and allele frequencies of the CDH1 polymorphism between colorectal tumor cases and normal samples (P = 0.472 and 0.508, respectively). Furthermore, no significant associations were observed between the CDH1 polymorphism status and age, gender, tumor stage, and tumor location of the colorectal tumor cases (all P>0.05). Conclusions: These results indicate that CDH1 -160 C>A polymorphism does not contribute to the genetic susceptibility of CRC and the polymorphism may not be a direct effect on the progression of the disease in Turkish CRC patients. Istanbul University Cerrahpasa Medical Faculty Hospital, Istanbul, Turkey This study was financially supported by Istanbul University Cerrahpasa Medical Faculty Hospital, Istanbul, Turkey |
| Databáze: | OpenAIRE |
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