Dose-Response Relationship of DNA and Recombinant Fowlpox Virus Prime-Boost HIV Vaccines: Implications for Future Trials
| Autor: | Robert De Rose, Stephen J. Kent, Mark T. Sullivan, Sean Emery, Ian A. Ramshaw, C. Jane Dale, David A. Cooper, David B. Boyle, Anthony D. Kelleher |
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| Rok vydání: | 2006 |
| Předmět: |
AIDS Vaccines
Vaccines Synthetic Cellular immunity Fowlpox virus Body Surface Area Immunogenicity Immunology Dose-Response Relationship Immunologic Biology Simian immunodeficiency virus medicine.disease_cause complex mixtures Virology DNA vaccination Vaccination Vaccines DNA medicine Animals Humans Macaca General Pharmacology Toxicology and Pharmaceutics HIV vaccine |
| Zdroj: | Human Vaccines. 2:134-136 |
| ISSN: | 1554-8619 1554-8600 |
| Popis: | Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies. |
| Databáze: | OpenAIRE |
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